Tapestri Single-cell DNA Acute Myeloid Leukemia Panel
Acute Myeloid Leukemia (AML) is a cancer that evolves from the proliferation of undifferentiated myeloid lineage cells which acquire sequential mutations. Somatic and gene mutations have been associated with the evolution of AML but, understanding the clonal architecture provides insight into which mutations are disease drivers, versus which are more informative of diagnosis, treatment response, and prognosis. Leverage single-cell genomics to reveal missing details that are lost in bulk sequencing. Uncover clonal evolution insights with precision; download the AML Tapestri panel today.
Advance your understanding of the genetic heterogeneity underpinning acute myeloid leukemia (AML) by targeting 20 genes with 127 amplicons for single-cell sequencing. Covering a combination of oncogenes and tumor suppressor genes, this panel is designed to cover some of the most commonly mutated genes associated with AML.
Clonal evolution and changes in two AML patients detected with a novel single-cell DNA sequencing platform.
Polyclonal heterogeneity: the new norm for secondary clinical resistance to targeted monotherapy in relapsed leukemia?
Wei, A. et. al., Cancer Discovery (2019)
Clonal selection with Ras pathway activation mediates secondary clinical resistance to selective FLT3 inhibition in acute myeloid leukemia.
McMahon, C. et. al., Cancer Discovery (2019)
High-throughput single-cell DNA sequencing of acute myeloid leukemia tumors with droplet microfluidics.
Eastburn, D. et. al., Genome Research (2018)
In pursuit of the leukemic stem cell: leveraging single cell genomics and proteomics to identify drivers of AML.
Single-cell Sequencing of Polyclonal Resistance to FLT3 Inhibitors in AML.
Catherine Smith, MD
Applying single-cell DNA techniques to examine clonal hematopoiesis and minimal residual disease.
Aaron Viny, MD MS
High-throughput Single Cell DNA Sequencing of Acute Myeloid Leukemia Tumors by Droplet Microfluidics.
Koichi Takahashi, MD,
University of Texas MD Anderson Cancer Center
Single-Cell DNA Analysis: Resolving Tumor Heterogeneity with Implications for Dynamic Therapy.
Dr. Alexander Pearl from University of Pennsylvania, and Dr. Catherine Smith, collaborator from UCSF
Dr. Ravi Majeti: Transforming the detection of minimal residual disease (MRD) with single-cell DNA analysis.
Dr. Cathy Smith: Beyond bulk sequencing: single-cell DNA analysis in cancer research and the potential of dynamic therapy.
Error Correction in Single-cell DNA Sequencing:
Finding Rare Allele for MRD Clone.